Norditropin FlexPro 15 mg/1.5 ml Growth-Hormone Pen

Norditropin FlexPro 15 mg/1.5 ml Growth-Hormone Pen

Brand: Novo Nordisk
Content: 15 mg recombinant somatropin per 1.5 ml (10 mg/ml)
Price: €149
Manufactured in: Europe

🧪 Product Overview

Norditropin FlexPro delivers 191-amino-acid recombinant somatropin (rDNA origin) in a single-use, pre-filled growth hormone pen designed for precision subcutaneous administration in controlled research. Each 1.5 ml pen contains 15 mg of somatropin (10 mg/ml concentration), with a molecular weight of 22,125 Da, formulated for research into growth-hormone deficiency (GHD), body composition shifts, and IGF-1-mediated regeneration.

Post-activation, the FlexPro pen remains stable at ≤25 °C for 3 weeks or 2–8 °C for 4 weeks, allowing convenient field-based protocols. Trials show robust support for lean-mass gain, height velocity normalization in pediatric GHD, and erythropoietic stimulation via the IGF-1 axis. All use is governed by WADA Prohibited List S2 due to doping relevance.

✅ Key Research Highlights

Paediatric growth acceleration:
Clinical data confirm normalized height velocity within 6 months in GHD subjects [NovoMedLink, FDA]

Body composition support:
Studies in adult GHD cohorts show ↑ lean mass and ↓ fat mass after 6–12 months [Norditropin.com]

Erythropoietic enhancement:
Somatropin elevates IGF-1 and erythropoietin, improving haemoglobin levels [FDA Access Data]

Convenient storage:
Remains stable for 3 weeks at ≤25 °C after first use — ideal for outpatient settings [Norditropin.com]

🧬 Suggested Laboratory Applications

Growth-hormone deficiency (GHD) modeling in pediatric and adult cohorts

Somatropin-driven body recomposition and lean-mass trials

IGF-1 mediated bone mineralization and BMD research

Erythropoiesis and hematologic growth factor studies

Subcutaneous peptide delivery system evaluation

📊 Technical Specifications

Field	Data
Chemical Name	Somatropin (rDNA origin, 191 amino acids)
Chemical Formula	C990H1528N262O300S7
Synonyms	Human Growth Hormone; rhGH; Norditropin; Recombinant hGH
Molecular Weight	22,125 Da
CAS Number	12629-01-5
Half-life	Not listed — typically 2–4 hours subcutaneous (research dependent)
Detection Window	Varies based on dosage and clearance pathway
Documented Benefits	↑ Growth velocity, ↑ lean mass, ↓ fat mass, ↑ BMD, ↑ EPO/IGF-1
Main Risks	Edema, injection-site rash, arthralgia, insulin resistance, rare intracranial hypertension
Total Active Compound	15 mg somatropin per pen (10 mg/ml × 1.5 ml)
Shelf-life	30 months (refrigerated, unopened); 3–4 weeks post-activation

❄️ PubChem-Supported Research Insights

Stimulates linear growth in pediatric GHD models

Enhances protein synthesis and lean mass retention in adult GHD

Modulates IGF-1 axis to support bone density improvements

Shown to improve red blood cell production via EPO stimulation

Offers convenient subcutaneous delivery with high compliance

⚠️ Documented Research Side Effects

Mild: Edema, arthralgia, injection-site rash

Moderate: Hyperglycaemia and reduced insulin sensitivity

Rare: Intracranial hypertension in long-term studies

Storage and refrigeration required to prevent protein degradation

🧯 Handling & Compliance

For Research Use Only — Not for human or veterinary treatment
Store refrigerated at 2–8 °C (unopened); post-activation use within 3 weeks at ≤25 °C
Use only with NovoFine or NovoTwist 8 mm single-use needles
Listed on WADA Prohibited List S2 — peptide hormone; exposure triggers anti-doping violations