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PEG-MGF 4 mg — Sterling Knight Pharmaceuticals

Brand: Sterling Knight Pharmaceuticals
Category: Injectable Peptide · IGF-1Ec Analogue (PEGylated MGF)
Content: 4 mg PEG-MGF (lyophilised powder)
Packaging: 1 sterile vial with flip-off cap + lab insert
Origin: United Kingdom
Price: €39
Research Notice: Laboratory use only. Not for human or veterinary application.

🧬 Product Overview

PEG-MGF is a PEGylated form of Mechano Growth Factor (IGF-1Ec), the damage-inducible splice variant of the IGF-1 gene.
Native MGF has an extremely short half-life; PEGylation increases stability and extends systemic exposure, enabling improved analysis of muscle-repair, regeneration, satellite-cell behaviour, and growth-factor signalling.

This longer-acting analogue is frequently used in:

• muscle-injury and regeneration pathway studies
• time-course signalling assays requiring extended peptide stability
• comparative IGF-1Ec vs. IGF-1Ea research
• anti-doping method development for growth-factor classes

🔬 Key Research Highlights

Origin & biology:
MGF (IGF-1Ec) is generated via alternative splicing of the IGF-1 gene following mechanical overload or tissue damage. Its E-domain displays biological activities distinct from IGF-1Ea. (Peer-reviewed PMC data)

Preclinical activity:
MGF E-peptide analogues have been reported to influence satellite cells, myoblast activity, and early-stage repair models, though findings vary and some synthetic fragments show limited potency. (Journal of Molecular Endocrinology)

Why PEGylate?
PEGylation increases peptide half-life by reducing renal clearance and proteolytic degradation, allowing more reliable PK/PD profiling. This enables longer sampling windows compared with native short-lived MGF. (PMC)

Anti-doping relevance:
MGF analogues, IGF-1 variants, and growth-factor mimetics fall under WADA S2 prohibited substances. Even trace exposure can trigger a positive test. (World Anti-Doping Agency)

🧬 Mechanism of Action (Simplified)

• Native MGF is expressed after mechanical load and tissue injury.
• Acts through distinct E-domain signalling linked to repair and early regeneration stages.
• PEGylation prolongs peptide survival, improving systemic exposure for research interrogation.
• Supports examination of IGF-1Ec-specific pathways versus mature IGF-1 signalling.

📊 Technical Specification Table

📚 Research Context & Applications

• Extended PK studies investigating IGF-1Ec-related pathways
• Muscle injury, repair, and satellite-cell activation models
• Comparative signalling vs. IGF-1Ea / mature IGF-1
• Anti-doping surveillance method development

⚠️ Side Effects / Risks (Class-Based Literature)

• Growth-factor modulation may alter endocrine signalling
• Potential off-target activation of proliferative pathways
• Doping-relevant substance — may produce a positive test
• Peptides must be handled with appropriate biosafety precautions

🧯 Compliance Notice

FOR RESEARCH USE ONLY.
Not for human or veterinary use. Not a dietary supplement or medicinal product.
Researchers are responsible for laboratory biosafety, SDS protocols, and adherence to all applicable regulations.
WADA Status: Prohibited under S2 — peptide hormones, growth factors, and related mimetics.