Meridia® 15 mg (Sibutramine HCl Monohydrate)
30 capsules · 15 mg sibutramine HCl · Meridia® (sibutramine) is a centrally acting SNRI research compound used for analytical and mechanistic studies of appetite signaling, monoamine reuptake inhibition, and sympathomimetic cardiovascular effects—supplied strictly for laboratory use only.
€ 29.00
Descripción
Meridia® 15 mg (Sibutramine HCl Monohydrate)
Brand: Bariatrics (Abbott)
Category: Centrally acting monoamine-reuptake modulator (SNRI) – Research chemical
Content: 30 capsules · 15 mg sibutramine HCl monohydrate per capsule
Price: €29
Manufactured in: Europe
Research Notice: FOR RESEARCH USE ONLY. Not for human or veterinary use.
🧪 Product Overview
Meridia® 15 mg contains sibutramine hydrochloride monohydrate, a centrally acting
serotonin–norepinephrine reuptake inhibitor (SNRI) historically indicated for weight management
until its withdrawal following the SCOUT cardiovascular-outcomes trial.
It is now used exclusively as a laboratory/analytical reference compound for studies on
monoamine signaling, appetite regulation, toxicology, and forensic method development.
Sibutramine increases synaptic concentrations of serotonin (5-HT) and
norepinephrine (NE) by blocking their reuptake transporters. Its active metabolites
(M1/M2) are chiefly responsible for appetite-suppression pathways and sympathetic activation.
✅ Key Research Highlights
Monoamine reuptake inhibition:
Blocks SERT and NET (± DAT) → ↑ 5-HT/NE levels → enhanced satiety signaling.
Documented extensively in DrugBank and PubChem entries.
Historical pharmacotherapy:
Originally approved for obesity management; later withdrawn (EU/US, 2010) due to increased risk of
non-fatal MI and stroke in high-risk cardiovascular patients (SCOUT trial – NEJM).
Anti-doping relevance:
Classified under WADA Stimulants (in-competition). Athletes must confirm status via Global DRO.
Laboratory value:
Used in metabolic, toxicological, chromatographic, and receptor-transporter profiling workflows.
🧬 Mechanism of Action (Simplified)
Sibutramine is metabolized into two active metabolites (M1 & M2) which:
- Block serotonin (SERT) and norepinephrine (NET) transporters
- Increase synaptic monoamines → enhanced satiety and reduced caloric intake
- Produce mild sympathetic activation → increased HR/BP in clinical history
This profile supports its use in monoamine and appetite-regulation research models.
📊 Scientific Data Table
| Field | Data |
|---|---|
| Chemical Name | Sibutramine hydrochloride monohydrate |
| Molecular Formula | C17H29Cl2NO (monohydrate salt, PubChem) |
| Molecular Weight | ~334.3 g/mol (monohydrate) |
| Synonyms | Meridia; Reductil; Sibutramine HCl; Sibutramine HCl Monohydrate |
| CAS Number | 125494-59-9 (monohydrate); 84485-00-7 (base) |
| PubChem CID | 64765 (monohydrate); 5210 (base) |
| Pharmacology | SNRI (± DAT) → appetite/satiety modulation via monoamine elevation |
| Doping Status | Stimulants – Prohibited in competition (WADA) |
📚 Research Background
- SCOUT Trial (NEJM): Increased non-fatal MI and stroke in high-risk cardiovascular groups → regulatory withdrawal.
- Mechanistic relevance: Appetite suppression linked to SERT/NET inhibition and downstream hypothalamic pathways.
- Toxicology interest: Cardiovascular, serotonergic, and sympathomimetic components evaluated in controlled studies.
⚠️ Documented Risks (Historical Medicinal Use)
- ↑ Heart rate and blood pressure
- Increased risk of non-fatal MI and stroke (SCOUT)
- Insomnia, dry mouth, headache, constipation
- Possible serotonin-related interactions (SSRIs/MAOIs)
🧯 Compliance & Legal Status
Regulation: Suspended/withdrawn in EU/US (2010). Not marketed as a medicinal product on this site.
Research-only: Supplied strictly for laboratory/analytical use.
Sport: Listed under WADA Stimulants (Prohibited In-Competition).
Researchers and athletes must verify local regulations and anti-doping rules.
📌 Important Notice
This compound is for laboratory research only.
Not for human consumption, therapeutic use, or veterinary application.
Users are responsible for compliance with local laws, regulations, and safety protocols.
There are no reviews yet.
