PEG-MGF 4 mg
PEG-MGF 4 mg is a PEGylated analogue of the IGF-1Ec splice-variant E-domain, engineered to extend the short-lived native MGF signal for controlled regeneration, repair, and growth-factor pathway research. Supplied as a lyophilised peptide vial for laboratory use only.
€ 39.00
Beschreibung
PEG-MGF 4 mg — Sterling Knight Pharmaceuticals
Brand: Sterling Knight Pharmaceuticals
Category: Injectable Peptide · IGF-1Ec Analogue (PEGylated MGF)
Content: 4 mg PEG-MGF (lyophilised powder)
Packaging: 1 sterile vial with flip-off cap + lab insert
Origin: United Kingdom
Price: €39
Research Notice: Laboratory use only. Not for human or veterinary application.
🧬 Product Overview
PEG-MGF is a PEGylated form of Mechano Growth Factor (IGF-1Ec), the damage-inducible splice variant of the IGF-1 gene.
Native MGF has an extremely short half-life; PEGylation increases stability and extends systemic exposure, enabling improved analysis of muscle-repair, regeneration, satellite-cell behaviour, and growth-factor signalling.
This longer-acting analogue is frequently used in:
- muscle-injury and regeneration pathway studies
- time-course signalling assays requiring extended peptide stability
- comparative IGF-1Ec vs. IGF-1Ea research
- anti-doping method development for growth-factor classes
🔬 Key Research Highlights
Origin & biology:
MGF (IGF-1Ec) is generated via alternative splicing of the IGF-1 gene following mechanical overload or tissue damage. Its E-domain displays biological activities distinct from IGF-1Ea. (Peer-reviewed PMC data)
Preclinical activity:
MGF E-peptide analogues have been reported to influence satellite cells, myoblast activity, and early-stage repair models, though findings vary and some synthetic fragments show limited potency. (Journal of Molecular Endocrinology)
Why PEGylate?
PEGylation increases peptide half-life by reducing renal clearance and proteolytic degradation, allowing more reliable PK/PD profiling. This enables longer sampling windows compared with native short-lived MGF. (PMC)
Anti-doping relevance:
MGF analogues, IGF-1 variants, and growth-factor mimetics fall under WADA S2 prohibited substances. Even trace exposure can trigger a positive test. (World Anti-Doping Agency)
🧬 Mechanism of Action (Simplified)
- Native MGF is expressed after mechanical load and tissue injury.
- Acts through distinct E-domain signalling linked to repair and early regeneration stages.
- PEGylation prolongs peptide survival, improving systemic exposure for research interrogation.
- Supports examination of IGF-1Ec-specific pathways versus mature IGF-1 signalling.
📊 Technical Specification Table
| Field | Data |
|---|---|
| Chemical name | PEGylated Mechano Growth Factor (PEG-MGF), PEG conjugate of IGF-1Ec E-domain |
| Chemical formula | Variable; PEGylation produces a molecular weight distribution depending on PEG chain length (refer to batch COA). |
| Synonyms | PEG-MGF · PEG-IGF-1Ec · PEG-Mechano Growth Factor |
| Molecular weight | Variable; PEG conjugates commonly fall in ~20–30 kDa range (illustrative; confirm on COA). |
| CAS number | No universal CAS; varies by PEG chain length and manufacturer. |
| Evidence summary |
IGF-1Ec expression induced by mechanical stress; reports of satellite-cell modulation and regeneration signalling; mixed activity findings for synthetic fragments; PEGylation improves half-life and PK window. |
| Total active content | 4 mg per lyophilised vial |
| Storage | Store dry, cool, and protected from light; refrigerate if required by COA. Use aseptic technique when reconstituting. |
| Origin | United Kingdom |
📚 Research Context & Applications
- Extended PK studies investigating IGF-1Ec-related pathways
- Muscle injury, repair, and satellite-cell activation models
- Comparative signalling vs. IGF-1Ea / mature IGF-1
- Anti-doping surveillance method development
⚠️ Side Effects / Risks (Class-Based Literature)
- Growth-factor modulation may alter endocrine signalling
- Potential off-target activation of proliferative pathways
- Doping-relevant substance — may produce a positive test
- Peptides must be handled with appropriate biosafety precautions
🧯 Compliance Notice
FOR RESEARCH USE ONLY.
Not for human or veterinary use. Not a dietary supplement or medicinal product.
Researchers are responsible for laboratory biosafety, SDS protocols, and adherence to all applicable regulations.
WADA Status: Prohibited under S2 — peptide hormones, growth factors, and related mimetics.
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